On the surface principles and approaches that prioritize transparency, collaboration, and openness in scientific research might appear to contradict with the need to safeguard the privacy of research participants or minimize threats to national or international security. Upon further inspection we see that engaging in open science is not an all or nothing endeavor. This panel brings together voices from the Office of Export and Secure Research Compliance,  the Privacy and Research Data Protection program, and University Libraries to discuss the compelling ethical reasons why both research security and open science are critical considerations as we strive to conduct collaborative research with partners from around the world.